Possible mechanisms of bidirectional nuclear transport during neuronal migration

Neuronal migration is a fundamental process of mammalian brain development. In migrating neurons, the nuclear membrane protein Nesprin-2 has been shown to serve as an adaptor pull nucleus along microtubule tracks. Current evidence that binds both minus-end-directed motor dynein well plus-end-directed kinesin. However, translocation neuronal long thought be primarily driven by motors. Intriguing questions could raised about role kinesin in transport and how activities opposing motors are coordinated through interactions with Nesprin. Combining from recent studies, we propose serves switchboard mediating bidirectional movements.